While still among the most explosive offenses in the league, the Bills haven't been quite as dominant in recent weeks. Detroit has only been defeated by more than one score in two games this season, and both of those losses came on the road. Even if Detroit doesn't upset Buffalo on Thanksgiving, the Lions can be competitive and give the Bills a scare. The Lions are finally meeting preseason expectations during their three-game winning streak. ![]() Here's a look at the Thanksgiving odds, along with a prediction against the spread and a best bet for each Thursday game.īuffalo Bills (-9.5) at Detroit Lions, 53.5 The Dallas Cowboys and Minnesota Vikings are home favorites. The New York Giants have the best odds to score the fewest points on the holiday schedule. The Buffalo Bills are favored to beat the Detroit Lions at FanDuel Sportsbook and be the highest-scoring team on Thanksgiving. ![]() In addition to the point spreads and over/unders, Thursday's schedule includes team totals and special prop bets. ![]() There are plenty of options available for anyone who is looking to make bets on the 2022 NFL Thanksgiving games.
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